Publications

32. Chadwick SR., Fazio EN., Etedali-Zadeh P., Genereaux J., Duennwald ML. and Lajoie P. 2019. A functional unfolded protein response is required for chronological aging in Saccharomyces cerevisiae. Curr Genet. In press

31. Ahmed A., Carter DE., Lajoie P. 2019. Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity. FEBS Lett. 593(15):1957-1973.

 

30. Lajoie P., Snapp EL. 2019. Size-Dependent Secretory Protein Reflux into the Cytosol in Association with Acute Endoplasmic Reticulum Stress. BioRxiv. 573428

29.  Schum M., Qing S., Lajoie P. and Laird DW. 2019. Destination and consequences of Panx1 and mutant expression in polarized MDCK cells. Exp Cell Res. 15;381(2):235-247

28. Chadwick SR. and Lajoie P. 2019. Endoplasmic reticulum stress coping mechanisms and lifespan regulation in health and diseases. Front. Cell Dev. Biol. 7:84. doi: 10.3389/fcell.2019.00084

27. Jiang Y., Berg MD., Genereaux J., Ahmed K., Duennwald ML., Brandl CJ. and Lajoie P. 2019. Sfp1 links TORC1 and cell growth regulation to the yeast SAGA‐complex component Tra1 in response to polyQ proteotoxicity. Traffic. Apr;20(4):267-283. includes cover image

26. Albakri MB, Jiang Y, Genereaux J and Lajoie P. 2018. Polyglutamine toxicity assays highlight the advantages of mScarlet for imaging in Saccharomyces cerevisiae. F1000Research, 7:1242

25. Jiang, Y., Di Gregorio, S., Albakri, M. B., Duennwald, M. L., Lajoie, P. 2018. Effect of Fluorescent Proteins on Fusion Partners Using Polyglutamine Toxicity Assays in Yeast. J. Vis. Exp. (141), e58748, doi:10.3791/58748.

24. Jiang Y., Digregorio SE., Duennwald ML. and Lajoie P. 2017. Polyglutamine toxicity in yeast uncovers phenotypic differences between fluorescent protein fusions. Traffic. Jan;18(1):58-70. doi: 10.1111/tra.12453.

23. Jiang Y., Chadwick SR. and Lajoie P. 2016. Endoplasmic reticulum stress: the cause and answer to Huntington's disease? Brain Research. 1648(Pt B):650-65. 

 

22. Chadwick SR., Pananos AD., Digregorio S., Park AE., Etedali-Zadeh P., Duennwald ML. and Lajoie P. 2016. A toolbox for rapid quantitative assessment of chronological lifespan and survival in Saccharomyces cerevisiae. Traffic. Jun;17(6):689-703. includes cover image.

 

21. Fazio EN., Jiang Y. and Lajoie P. 2014. Endoplasmic reticulum homeostasis in Huntington’s disease. Journal of Anatomy (Austin). 1(5): 4

 

20. Lajoie P.*, Fazio EN. and Snapp EL.* 2014. Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress in Diseases. 1, 27– 39 *co-corresponding authors

 

19. Berger AC., Kelly JJ., Lajoie P., Shao Q. and Laird DW. 2014. Skin disease and non-syndromic hearing loss-linked Cx30 mutations exhibit several distinct cellular pathologies. J Cell Sci. Apr 15;127 (Pt 8):1751-64

 

18. Lajoie P., Moir RD., Willis IM., Snapp EL. 2012. Kar2p availability defines various forms of endoplasmic reticulum stress in living cells.  Mol. Biol. Cell. 23(5): 955-64

 

17. Snapp EL and Lajoie P. 2011. Imaging of Membrane Systems and Membrane Traffic in Living Cells. Cold Spring Harb Protoc. 2011 (11): 1295-1304.

 

16. Snapp EL and Lajoie P. 2011. Activating Photoactivatable Proteins with Laser Light to Visualize Membrane Systems and Membrane Traffic in Living Cells. Cold Spring Harb Protoc. 2011 (11): 1368-1369.

 

15. Snapp EL and Lajoie P. 2011. Photobleaching Regions of Living Cells to Monitor Membrane Traffic. Cold Spring Harb Protoc. 2011 (11): 1366-1367.

 

14. Snapp EL and Lajoie P. 2011. Time-Lapse Imaging of Membrane Traffic in Living Cells. Cold Spring Harb Protoc. 2011 (11):1362-1365.

 

13. Lajoie P., Snapp EL. 2011. Changes in BiP availability reveal hypersensitivity to acute ER stress in cells expressing mutant huntingtin. J. Cell Sci. 124:3332-3343.

 

12. Lajoie P., Snapp EL. 2010. Formation and toxicity of polyglutamine oligomers in living cells. PLoS One. 5(12):e15245

 

11. Benedix J, Lajoie P, Jaiswal H, Burgard C, Greiner M, Jung M, Zimmermann R, Rospert S, Snapp EL and Dudek J. 2010. BiP modulates the affinity of its co-chaperone ERj1 to ribosomes. J Biol. Chem. 285(47):36427-33

 

10. Müller L, de Escauriaza MD, Lajoie P, Theis M, Jung M, Müller A, Burgard C, Greiner M, Snapp EL, Dudek J, Zimmermann R. 2010. Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans. Mol Biol Cell. (5):691-703.

 

9. Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, Nabi IR, Roberge M. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One. (9):e7124.

 

8. Lajoie P, Kojic LD, Nim S, Li L, Dennis JW, Nabi IR. 2009. Caveolin-1 regulation of dynamin-dependent, raft-mediated endocytosis of cholera toxin-B sub-unit occurs independently of caveolae. J Cell Mol Med. (9B):3218-25.

 

7. Lajoie P*, Goetz JG*, Dennis JW, Nabi IR. 2009. Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane. J Cell Biol. 185(3):381-5. *equal contribution

 

6. Goetz JG*, Lajoie P*, Wiseman SM, Nabi IR. 2008. Caveolin-1 in tumor progression: the good, the bad and the ugly. Cancer Metastasis Rev. (4):715-35. *equal contribution

 

5. Goetz JG, Joshi B, Lajoie P, Strugnell SS, Scudamore T, Kojic LD, Nabi IR. 2008. Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol.  180(6):1261-75

 

3. Lajoie P, Partridge EA, Guay G, Goetz JG, Pawling J, Lagana A, Joshi B, Dennis JW, Nabi IR. 2007. Plasma membrane domain organization regulates  EGFR signaling in tumor cells. J Cell Biol. 179(2):341-56. includes cover image

 

4. Lajoie P, Nabi IR. 2007. Regulation of raft-dependent endocytosis. J Cell Mol Med. (4):644-53.

 

2. Kojic LD, Joshi B, Lajoie P, Le PU, Cox ME, Turbin DA, Wiseman SM, Nabi IR. 2007. Raft-dependent endocytosis of autocrine motility factor is phosphatidylinositol 3-kinase-dependent in breast carcinoma cells. J Biol Chem. 5;282(40):29305-13.

 

1. Lajoie P, Guay G, Dennis JW, and Nabi IR. 2005. The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies. J Cell Sci.  1;118(Pt 9):1991-2003. includes cover image

 

 

Book and Methods Chapters

 

3. Lajoie P. Snapp EL. 2013. Detecting soluble PolyQ oligomers and investigating their impact on cells. Methods in Molecular Biology. 1017:229-39.

 

2. Snapp, EL, Lajoie P. 2010. Imaging of membrane systems and membrane traffic in living cells. Section 2.33. Goldman RD, Swedlow, JR, Spector DL. editors. In Live Cell Imaging : a laboratory manual.  Second edition. Cold Spring Harbor Laboratory press.

 

1. Lajoie P, Nabi IR. 2010. Lipid rafts caveolae and their endocytosis. Chapter 3. Bourne GH., Danielli JF, Jeon KW, Friedlander M, Jarvik J. series editors. In International Review in Cell and Molecular Biology. Volume 28. 282:135-63

“Science, my lad, is made up of mistakes, but they are mistakes which it is useful to make, because they lead little by little to the truth.”

Jules Verne

© 2014 by Patrick Lajoie.
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Department of Anatomy and Cell Biology

University of Western Ontario

London, ON N6A 5C1 CANADA

plajoie3@uwo.ca

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